Lehrinhalte
Introduction into the methods for the lab-scale und preparation of fluoroorganic compounds. The focus will also be on the unique property profile of fluorochemicals, and how that can be utilized for the design of functional materials, industrial chemicals and pharmaceuticals:
• Properties of fluoroorganic compounds
• Environmental impact of fluoroorganic chemistry
• Survey of synthetic methods and reactivity
• Fluoroorganic materials: the chemistry of liquid crystals
• Fluoropharmaceuticals and diagnostics: structure-property relationships
• Fluorous synthesis and catalysis
Literatur
1. P. Kirsch. Modern Fluoroorganic Chemistry: Synthesis, Reactivity, Applications (2nd ed). Wiley-VCH, Weinheim (2013) (doi: 10.1002/9783527651351)
Voraussetzungen
Bachelor degree in chemistry or materials science. It is highly recommended to obtain a good background of general and organic chemistry.
Offizielle Kursbeschreibung
• Understanding of the physical and chemical property profile of fluoroorganic compounds
• Overview on the synthetic toolbox for the synthesis of fluoroorganic compounds
• Highlights on various applications which depend critically on fluoroorganic compounds
Online-Angebote
moodle
Course Contents
[b]Content[/b]
Introduction into the methods for the lab-scale und preparation of fluoroorganic compounds. The focus will also be on the unique property profile of fluorochemicals, and how that can be utilized for the design of functional materials, industrial chemicals and pharmaceuticals:
• Properties of fluoroorganic compounds
• Environmental impact of fluoroorganic chemistry
• Survey of synthetic methods and reactivity
• Fluoroorganic materials: the chemistry of liquid crystals
• Fluoropharmaceuticals and diagnostics: structure-property relationships
• Fluorous synthesis and catalysis
Literature
1. P. Kirsch. Modern Fluoroorganic Chemistry: Synthesis, Reactivity, Applications (2nd ed). Wiley-VCH, Weinheim (2013) (doi: 10.1002/9783527651351)
2. A. Haupt. Organic and Inorganic Fluorine Chemistry: Methods and Applications. De Gruyter, Berlin (2021) (doi: 10.1515/9783110659337)
3. J. Han, A. M. Remete, L. S. Dobson, L. Kiss, K. Izawa, H. Moriwaki, V. A. Soloshonok, D. O’Hagan. Next generation organofluorine containing blockbuster drugs. J. Fluorine Chem. 239, 109639 (2020) (doi: 10.1016/j.jfluchem.2020.109639)
4. Y. Ogawa, E. Tokunaga, O. Kobayashi, K. Hirai, N. Shibata. Current contributions of organofluorine compounds to the agrochemical industry. iScience (2020) (doi: 10.1016/j.isci.2020.101467)
Online Offerings
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- Lehrende: Peer Kirsch